Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.[5][6]
This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease.[7][8][9][10] Multiple transcript variants encoding distinct isoforms have been identified for this gene.[11]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118257 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025969 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (March 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250. S2CID 547080.
- ^ Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
- ^ Harman JL, Sayers J, Chapman C, Pellet-Many C (2020-07-21). "Emerging Roles for Neuropilin-2 in Cardiovascular Disease". International Journal of Molecular Sciences. 21 (14): 5154. doi:10.3390/ijms21145154. PMC 7404143. PMID 32708258.
- ^ Kofler N, Simons M (May 2016). "The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature". Current Opinion in Hematology. 23 (3): 260–7. doi:10.1097/MOH.0000000000000233. PMC 4957701. PMID 26849476.
- ^ Peng K, Bai Y, Zhu Q, Hu B, Xu Y (February 2019). "Targeting VEGF-neuropilin interactions: a promising antitumor strategy". Drug Discovery Today. 24 (2): 656–664. doi:10.1016/j.drudis.2018.10.004. PMID 30315890. S2CID 52979538.
- ^ Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H (November 1997). "Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice". Neuron. 19 (5): 995–1005. doi:10.1016/s0896-6273(00)80392-x. PMID 9390514. S2CID 17769318.
- ^ "Entrez Gene: NRP2 neuropilin 2".