A neuropod cell is a specialized enteroendocrine cell (i.e., sensory epithelial cell) within the gut that is capable of synapsing with afferent nerves.[2][3] Previously, transmission of sensory signals from enteroendocrine cells were thought to only occur in a paracrine fashion, in which secreted peptide hormones diffused through the lamina propria and contacted either intrinsic or extrinsic neurons, entered the circulation, and/or acted on specific target tissues.[4][5] However, neuropod cells, discovered by Dr. Diego V. Bohórquez in 2015 and later coined in 2018, were observed forming synaptic connections with nerves in the mucosa of the small and large intestine of rodents.[3][6] These synapses were revealed to involve neurons originating from the dorsal root ganglia and the vagal nodose ganglia of the spinal cord, which suggested that sensory information from the gut lumen could be conveyed to the brain within milliseconds of activation.[6] Also, it was found that these neuropod cells contained both pre- and postsynaptic proteins, suggesting that information could not only be conveyed to, but also received by neurons.[3][6][7] This newly found transmission mechanism of luminal senses from the gut to the brain may spark a new area of exploration within the gut-brain axis and sensory neurobiology.