Neurotrophin-3

NTF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B8K, 1BND, 1NT3, 3BUK
Identifiers
Aliases	NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
External IDs	OMIM: 162660; MGI: 97380; HomoloGene: 1896; GeneCards: NTF3; OMA:NTF3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 5,432,108 bp[1] End 5,521,536 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 60.45 cM Start 126,078,375 bp[2] End 126,143,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery ascending aorta left coronary artery Descending thoracic aorta right ovary left ovary testicle saphenous vein Top expressed in external naris ciliary body ascending aorta iris corneal stroma conjunctival fornix maxillary prominence substantia nigra pineal gland medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neurotrophin p75 receptor binding neurotrophin receptor binding chemoattractant activity growth factor activity signaling receptor binding protein binding Cellular component cytoplasmic vesicle extracellular region extracellular space synaptic vesicle axon dendrite Biological process regulation of apoptotic process negative regulation of neuron apoptotic process regulation of neuron differentiation activation of protein kinase B activity neuron projection morphogenesis activation of GTPase activity positive regulation of receptor internalization transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell migration cell-cell signaling positive regulation of peptidyl-serine phosphorylation induction of positive chemotaxis negative regulation of peptidyl-tyrosine phosphorylation positive regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of actin cytoskeleton reorganization signal transduction positive chemotaxis nervous system development regulation of signaling receptor activity positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling peripheral nervous system development memory nerve development nerve growth factor signaling pathway modulation of chemical synaptic transmission positive regulation of neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4908 18205 Ensembl ENSG00000185652 ENSMUSG00000049107 UniProt P20783 P20181 RefSeq (mRNA) NM_001102654 NM_002527 NM_001164034 NM_001164035 NM_008742 RefSeq (protein) NP_001096124 NP_002518 NP_001157506 NP_001157507 NP_032768 Location (UCSC) Chr 12: 5.43 – 5.52 Mb Chr 6: 126.08 – 126.14 Mb PubMed search [3] [4]
Wikidata
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Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.^[5][6]

The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor).^[7]