Neurotrophin-4 (NT-4),[5] also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.[6] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.[7][8] NT-4 was first discovered and isolated from xenopus and viper in the year 1991 by Finn Hallbook et.al[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000225950 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074121 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ibáñez CF, Ernfors P, Timmusk T, Ip NY, Arenas E, Yancopoulos GD, Persson H (April 1993). "Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion". Development. 117 (4): 1345–1353. doi:10.1242/dev.117.4.1345. PMID 8404536.
- ^ "Entrez Gene: neurotrophin 4".
- ^ Klein R, Lamballe F, Bryant S, Barbacid M (May 1992). "The trkB tyrosine protein kinase is a receptor for neurotrophin-4". Neuron. 8 (5): 947–956. doi:10.1016/0896-6273(92)90209-v. PMID 1375038. S2CID 9772551.
- ^ Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, et al. (February 1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells". Neuron. 10 (2): 137–149. doi:10.1016/0896-6273(93)90306-c. PMID 7679912. S2CID 46072027.
- ^ Hallböök F, Ibáñez CF, Persson H (May 1991). "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary". Neuron. 6 (5): 845–858. doi:10.1016/0896-6273(91)90180-8. PMID 2025430. S2CID 17772282.