Nicastrin

NCSTN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCSTN, ATAG1874, nicastrin
External IDsOMIM: 605254; MGI: 1891700; HomoloGene: 41029; GeneCards: NCSTN; OMA:NCSTN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001290184
NM_001290186
NM_015331
NM_001349729

NM_021607

RefSeq (protein)

NP_001277113
NP_001277115
NP_056146
NP_001336658

NP_067620

Location (UCSC)Chr 1: 160.34 – 160.36 MbChr 1: 171.89 – 171.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.[5][6][7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162736Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003458Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NCSTN nicastrin".
  6. ^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  7. ^ Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P (Sep 2000). "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing". Nature. 407 (6800): 48–54. Bibcode:2000Natur.407...48Y. doi:10.1038/35024009. PMID 10993067. S2CID 4339220.