Nicholas II of Niemodlin (Polish: Mikołaj II Niemodliński; c. 1462 – 27 June 1497), was a Duke of Opole-Brzeg-Strzelce-Niemodlin in 1476 (as co-ruler of his father) and sole Duke of Niemodlin from 1476 until his death.
He was the third son of Duke Nicholas I of Opole by his wife Agnes, daughter of Duke Louis II of Brzeg.