Nicholas of Methone (died 1160/1166) was a Byzantine theologian and philosopher who served as the bishop of Methone from around 1150.
Nicholas wrote hagiography, hymnody, theology, biblical exegesis and panegyric. His most widely read works were his treatises against the practices and doctrines of the Latin Church, but modern scholarship regards his Refutation of the neoplatonist philosopher Proclus as his greatest work. Nicholas was close to the Emperor Manuel I Komnenos and served him as an advisor. He was involved in the major controversies over Bogomilism (1140s) and the writings of Soterichos Panteugenos (1155–1157).