Nicolas de la Salle (died 31 December 1710) was the first commissary appointed by the French King in the colony of Louisiana. He was the adversary of Jean-Baptiste Le Moyne de Bienville and eventually responsible for his removal from the office of governor.
La Salle was part of the René-Robert Cavelier, Sieur de La Salle expedition of 1682, in which all of the Mississippi basin was claimed for France.
He was also the brother-in-law of René-Robert Cavelier, as Nicolas married Robert's sister.