Prince Nikolai Borisovich Yusupov | |
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| Born | October 15, 1750 |
| Died | July 15, 1831 (aged 80) |
| Spouse(s) | Tatiana Vasilievna Yusupova (m. 1793) |
| Children | Boris Nikolaevich Yusupov |
| Parent(s) | Boris Grigoryevich Yusupov Irina Zinovieva |
| Relatives | Eudokia Yusupova (older sister) |
Prince Nikolai Borisovich Yusupov (Russian: Князь Никола́й Бори́сович Юсу́пов; 26 October [O.S. 15 October] 1750 – 15 July 1831) was a Russian nobleman and art collector of the House of Yusupov.