Nisoldipine

Nisoldipine
Skeletal formula of nisoldipine
Ball-and-stick model of the nisoldipine molecule
Clinical data
Trade namesSular, Baymycard, Syscor
AHFS/Drugs.comMonograph
MedlinePlusa696009
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability4–8%
Protein binding>99%
MetabolismCYP3A4
Elimination half-life7–12 hours
Excretion70–80% via urine
Identifiers
  • (RS)-Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.058.534 Edit this at Wikidata
Chemical and physical data
FormulaC20H24N2O6
Molar mass388.420 g·mol−1
3D model (JSmol)
  • CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)c2ccccc2[N+](=O)[O-])C(=O)OC
  • InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
  • Key:VKQFCGNPDRICFG-UHFFFAOYSA-N
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Nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. It is a calcium channel blocker of the dihydropyridine class. It is sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels.[1]

It was patented in 1975 and approved for medical use in 1990.[2]

  1. ^ Knorr AM (April 1995). "Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?". The American Journal of Cardiology. 75 (13): 36E–40E. doi:10.1016/S0002-9149(99)80446-9. PMID 7726122.
  2. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 464. ISBN 9783527607495.