Nitrogen mustard

HN1 (bis(2-chloroethyl)ethylamine)
HN2 (bis(2-chloroethyl)methylamine, mustine)
HN3 (tris(2-chloroethyl)amine)

Nitrogen mustards (NMs) are cytotoxic organic compounds with the bis(2-chloroethyl)amino ((ClC2H4)2NR) functional group.[1] Although originally produced as chemical warfare agents,[2][3] they were the first chemotherapeutic agents for treatment of cancer.[4] Nitrogen mustards are nonspecific DNA alkylating agents.

  1. ^ "Mustards". The IUPAC Compendium of Chemical Terminology. 2014. doi:10.1351/goldbook.M04071.
  2. ^ Nitrogen mustard gas was stockpiled by several nations during the Second World War, but it was never used in combat.Daniel C. Keyes; Jonathan L. Burstein; Richard B. Schwartz; Raymond E. Swienton (2004). Medical Response to Terrorism: Preparedness and Clinical Practice. Lippincott Williams & Wilkins. p. 16. ISBN 978-0781749862 – via books.google.com.
  3. ^ Centers for Disease Control and Prevention (April 4, 2013). "Facts About Nitrogen Mustards". cdc.gov. Archived from the original on September 3, 2013. Retrieved September 12, 2013.
  4. ^ Chabner, Bruce A.; Roberts, Thomas G. (2005). "Chemotherapy and the war on cancer". Nature Reviews Cancer. 5 (1): 65–72. doi:10.1038/nrc1529. PMID 15630416. S2CID 205467419.