Nizofenone

Nizofenone
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N06BX10 (WHO) ;
Identifiers
	IUPAC name (2-chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone;
CAS Number	54533-85-6;
PubChem CID	4514;
ChemSpider	4357 ;
UNII	7A2NOC3R88;
CompTox Dashboard (EPA)	DTXSID401014745 DTXSID5048637, DTXSID401014745 ;
Chemical and physical data
Formula	C21H21ClN4O3
Molar mass	412.87 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccccc1C(=O)c3cc([N+]([O-])=O)ccc3n2ccnc2CN(CC)CC;
	InChI InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3 ; Key:WZGBZLHGOVJDET-UHFFFAOYSA-N ;
	(verify)

Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.^[1]^[2]^[3]^[4]

^ Ohta T, Kikuchi H, Hashi K, Kudo Y (March 1986). "Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study". Journal of Neurosurgery. 64 (3): 420–426. doi:10.3171/jns.1986.64.3.0420. PMID 3512795.
^ Yasuda H, Izumi N, Nakanishi M, Maruyama Y (1988). "Brain Protection Against Oxygen Deficiency by Nizofenone". Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology. Vol. 222. pp. 403–10. doi:10.1007/978-1-4615-9510-6_48. ISBN 978-1-4615-9512-0. PMID 3364265.
^ Yasuda H, Nakajima A (1993). "Brain protection against ischemic injury by nizofenone". Cerebrovascular and Brain Metabolism Reviews. 5 (4): 264–276. PMID 8110594.
^ Matsumoto Y, Aihara K, Kamata T, Goto N (September 1994). "Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation". European Journal of Pharmacology. 262 (1–2): 157–161. doi:10.1016/0014-2999(94)90039-6. PMID 7813567.

[1] Ohta T, Kikuchi H, Hashi K, Kudo Y (March 1986). "Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study". Journal of Neurosurgery. 64 (3): 420–426. doi:10.3171/jns.1986.64.3.0420. PMID 3512795.

[2] Yasuda H, Izumi N, Nakanishi M, Maruyama Y (1988). "Brain Protection Against Oxygen Deficiency by Nizofenone". Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology. Vol. 222. pp. 403–10. doi:10.1007/978-1-4615-9510-6_48. ISBN 978-1-4615-9512-0. PMID 3364265.

[3] Yasuda H, Nakajima A (1993). "Brain protection against ischemic injury by nizofenone". Cerebrovascular and Brain Metabolism Reviews. 5 (4): 264–276. PMID 8110594.

[4] Matsumoto Y, Aihara K, Kamata T, Goto N (September 1994). "Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation". European Journal of Pharmacology. 262 (1–2): 157–161. doi:10.1016/0014-2999(94)90039-6. PMID 7813567.

[1]

[2]

[3]

[4]