Non-competitive inhibition

Not to be confused with Uncompetitive inhibitor.
"Non-competitive" redirects here. For other uses, see Competition.

Non-competitive inhibition is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme and binds equally well to the enzyme whether or not it has already bound the substrate.[1] This is unlike competitive inhibition, where binding affinity for the substrate in the enzyme is decreased in the presence of an inhibitor.

The inhibitor may bind to the enzyme whether or not the substrate has already been bound, but if it has a higher affinity for binding the enzyme in one state or the other, it is called a mixed inhibitor.[1]

  1. ^ a b Strelow J, Dewe W, Iversen PW, Brooks HB, Radding JA, McGee J, Weidner J (2004). "Mechanism of Action Assays for Enzymes". In Markossian S, Grossman A, Brimacombe K, Arkin M, Auld D, Austin CP, et al. (eds.). Assay Guidance Manual. Eli Lilly & Company and the National Center for Advancing Translational Sciences. PMID 22553872.