Norepinephrine transporter

SLC6A2
Identifiers
AliasesSLC6A2, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
External IDsOMIM: 163970; MGI: 1270850; HomoloGene: 816; GeneCards: SLC6A2; OMA:SLC6A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001043
NM_001172501
NM_001172502
NM_001172504

NM_009209

RefSeq (protein)

NP_001034
NP_001165972
NP_001165973
NP_001165975

NP_033235

Location (UCSC)Chr 16: 55.66 – 55.71 MbChr 8: 93.69 – 93.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.[5]

NET is a monoamine transporter and is responsible for the sodium-chloride (Na+/Cl)-dependent reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD.[6][7] There is evidence that single-nucleotide polymorphisms in the NET gene (SLC6A2) may be an underlying factor in some of these disorders.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103546Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055368Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pacholczyk T, Blakely RD, Amara SG (March 1991). "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter". Nature. 350 (6316): 350–4. Bibcode:1991Natur.350..350P. doi:10.1038/350350a0. PMID 2008212. S2CID 4333895.
  6. ^ Cite error: The named reference Schroeter was invoked but never defined (see the help page).
  7. ^ a b Tellioglu T, Robertson D (November 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Reviews in Molecular Medicine. 2001 (29): 1–10. doi:10.1017/S1462399401003878. PMID 14987367. S2CID 30965333.