| Conference | IHSA |
|---|---|
| Founded | 2001 |
| No. of teams | 21 |
| Region | Northwest and North-central Illinois (Carroll, Jo Daviess, Lee, Ogle, Stephenson, Whiteside and Winnebago counties) |
| Official website | NUIC Football |
| Locations | |
 The Northwest Upstate Illini Conference within Illinois | |
The Northwest Upstate Illini Conference is a high school conference in northwest and north central Illinois. The conference participates in athletics and activities in the Illinois High School Association. The conference comprises 20 small public high schools and one small private school, with enrollments between 60-340 students in Carroll, Jo Daviess, Lee, Ogle, Stephenson, Whiteside, and Winnebago counties.