Notch 4

NOTCH4
Identifiers
Aliases	NOTCH4, INT3, notch 4, notch receptor 4
External IDs	OMIM: 164951; MGI: 107471; HomoloGene: 3351; GeneCards: NOTCH4; OMA:NOTCH4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,224,067 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,807,477 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lung; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; lactiferous gland; ; left ventricle; ; right auricle; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; myometrium;
	Top expressed in
	external carotid artery; ; tail of embryo; ; gastrula; ; internal carotid artery; ; right lung; ; right lung lobe; ; left lung; ; lumbar subsegment of spinal cord; ; myocardium of ventricle; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein heterodimerization activity; calcium ion binding; signaling receptor activity; Notch binding;
Cellular component	integral component of membrane; cytosol; endoplasmic reticulum membrane; membrane; Golgi membrane; integral component of plasma membrane; nucleoplasm; extracellular region; cell surface; nucleus; plasma membrane;
Biological process	regulation of transcription, DNA-templated; negative regulation of cell differentiation; endothelial cell morphogenesis; negative regulation of endothelial cell differentiation; morphogenesis of a branching structure; transcription, DNA-templated; mammary gland development; positive regulation of transcription, DNA-templated; multicellular organism development; positive regulation of transcription of Notch receptor target; branching involved in blood vessel morphogenesis; cell fate determination; endothelial cell differentiation; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; cell differentiation; regulation of developmental process; vasculature development; wound healing; hemopoiesis; miRNA-mediated gene silencing by inhibition of translation; positive regulation of Notch signaling pathway; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4855
	18132
ENSG00000234876; ENSG00000238196; ENSG00000204301; ENSG00000232339; ENSG00000223355;
	ENSG00000235396; ENSG00000206312
	ENSMUSG00000015468
	Q99466
	P31695
	NM_004557
	NM_010929
	NP_004548
	NP_035059
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenic locus notch homolog 4 (Notch 4) is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.^[5]

^ ^a ^b ^c ENSG00000238196, ENSG00000204301, ENSG00000232339, ENSG00000223355, ENSG00000235396, ENSG00000206312 GRCh38: Ensembl release 89: ENSG00000234876, ENSG00000238196, ENSG00000204301, ENSG00000232339, ENSG00000223355, ENSG00000235396, ENSG00000206312 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015468 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Feb 1995). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.

[refGRCh38Ensembl-1] ENSG00000238196, ENSG00000204301, ENSG00000232339, ENSG00000223355, ENSG00000235396, ENSG00000206312 GRCh38: Ensembl release 89: ENSG00000234876, ENSG00000238196, ENSG00000204301, ENSG00000232339, ENSG00000223355, ENSG00000235396, ENSG00000206312 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015468 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835890-5] Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Feb 1995). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.

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