Notch proteins

Notch (LNR) domain
Structure of a prototype LNR module from human Notch 1[1]
Identifiers
SymbolNotch
PfamPF00066
InterProIPR000800
SMARTSM00004
PROSITEPS50258
OPM superfamily462
OPM protein5kzo
Membranome19
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Notch proteins are a family of type 1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in animals. The Notch extracellular domain mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling. The Notch intracellular domain acts as a transcriptional activator when in complex with CSL family transcription factors. Members of this type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD). Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. Much of what is known about Notch function comes from studies done in Caenorhabditis elegans (C.elegans) and Drosophila melanogaster. Human homologs have also been identified, but details of Notch function and interactions with its ligands are not well known in this context.

  1. ^ Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC (June 2003). "Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1". Biochemistry. 42 (23): 7061–7. doi:10.1021/bi034156y. PMID 12795601.