| Date | 13 November 2021 |
|---|---|
| Venue | Litoral Penitentiary |
| Location | Guayaquil, Ecuador |
| Coordinates | 02°03′09″S 79°56′42″W / 2.05250°S 79.94500°W |
| Type | Prison riot, massacre |
| Cause | Gang rivalry |
| Deaths | 68 inmates |
| Non-fatal injuries | 25 |
The November 2021 Guayaquil prison riot occurred on 13 November 2021 at the Litoral Penitentiary in Guayaquil, Ecuador, killing at least 68 people and injuring 25.