Nuclear receptor 4A1

NR4A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QW4, 3V3E, 3V3Q, 4JGV, 4KZI, 4KZJ, 4KZM, 4RZE, 4RZF, 4RZG, 4RE8, 4REE, 4REF, 4WHF, 4WHG
Identifiers
Aliases	NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3, nuclear receptor subfamily 4 group A member 1, NH41
External IDs	OMIM: 139139; MGI: 1352454; HomoloGene: 1612; GeneCards: NR4A1; OMA:NR4A1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,022,832 bp[1] End 52,059,507 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 101,152,150 bp[2] End 101,172,676 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa left uterine tube gallbladder left ovary tibial nerve popliteal artery tibial arteries right ovary muscle of thigh vena cava Top expressed in granulocyte adrenal gland plantaris muscle triceps brachii muscle vastus lateralis muscle tibialis anterior muscle extensor digitorum longus muscle muscle of thigh parotid gland medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding steroid hormone receptor activity nuclear receptor activity protein binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding glucocorticoid receptor binding Cellular component nuclear membrane nucleoplasm nucleus cytoplasm cytosol transcription regulator complex Biological process regulation of transcription, DNA-templated positive regulation of endothelial cell proliferation negative regulation of cell cycle cellular response to fibroblast growth factor stimulus transcription, DNA-templated cell migration involved in sprouting angiogenesis endothelial cell chemotaxis cellular response to corticotropin-releasing hormone stimulus cellular response to vascular endothelial growth factor stimulus transcription initiation from RNA polymerase II promoter fat cell differentiation regulation of type B pancreatic cell proliferation signal transduction steroid hormone mediated signaling pathway positive regulation of transcription by RNA polymerase II intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3164 15370 Ensembl ENSG00000123358 ENSMUSG00000023034 UniProt P22736 P12813 RefSeq (mRNA) NM_001202233 NM_001202234 NM_002135 NM_173157 NM_173158 NM_010444 RefSeq (protein) NP_001189162 NP_001189163 NP_002126 NP_775180 NP_002126.2 NP_775180.1 NP_034574 Location (UCSC) Chr 12: 52.02 – 52.06 Mb Chr 15: 101.15 – 101.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene.^[5][6]

Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family^[7] of intracellular transcription factors.^[6][8] NR4A1 is involved in cell cycle mediation, inflammation and apoptosis.^[9]

Nuclear receptor 4A1 plays a key role in mediating inflammatory responses in macrophages.^[9] In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells.^[10]

Expression is inducible by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[5]