Nuclear receptor co-repressor 1

NCOR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EQR, 3H52, 3KMZ, 3N00, 4MDD, 4WVD
Identifiers
Aliases	NCOR1, N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR, nuclear receptor corepressor 1
External IDs	OMIM: 600849; MGI: 1349717; HomoloGene: 38166; GeneCards: NCOR1; OMA:NCOR1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	16,218,185 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,349,367 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; epithelium of colon; ; Achilles tendon; ; ventricular zone; ; testicle; ; gonad; ; mucosa of transverse colon; ; buccal mucosa cell; ; ganglionic eminence; ; corpus callosum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural layer of retina; ; otic vesicle; ; Rostral migratory stream; ; lacrimal gland; ; saccule; ; granulocyte; ; epithelium of small intestine; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; histone deacetylase binding; thyroid hormone receptor binding; protein binding; nuclear receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding; sequence-specific DNA binding;
Cellular component	histone deacetylase complex; membrane; transcription repressor complex; Sin3 complex; spindle microtubule; nucleus; nucleoplasm; cytosol; mitotic spindle;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of production of miRNAs involved in gene silencing by miRNA; spindle assembly; negative regulation of JNK cascade; regulation of fatty acid transport; circadian rhythm; transcription, DNA-templated; regulation of lipid metabolic process; chromatin organization; negative regulation of transcription, DNA-templated; negative regulation of androgen receptor signaling pathway; locomotor rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	9611
	20185
	ENSG00000141027
	ENSMUSG00000018501
	O75376
	Q60974
	NM_001190438; NM_001190440; NM_006311
	NM_001252313; NM_011308; NM_177229
	NP_001177367; NP_001177369; NP_006302
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.^[5]^[6]

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.^[5]^[7]

Loss of function of this protein significantly increases the strength and power of mouse muscles.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141027 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018501 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK (October 1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature. 377 (6548): 397–404. Bibcode:1995Natur.377..397H. doi:10.1038/377397a0. PMID 7566114. S2CID 4230850.
^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (September 1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. Bibcode:1998PNAS...9510860W. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.
^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA. 95 (18): 10860–5. Bibcode:1998PNAS...9510860W. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.
^ Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J (2011). "NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function". Cell. 147 (4): 827–839. doi:10.1016/j.cell.2011.10.017. PMC 3225739. PMID 22078881.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141027 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018501 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Horlein_1995-5] Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK (October 1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature. 377 (6548): 397–404. Bibcode:1995Natur.377..397H. doi:10.1038/377397a0. PMID 7566114. S2CID 4230850.

[pmid9724795-6] Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (September 1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. Bibcode:1998PNAS...9510860W. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.

[Wang_1998-7] Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA. 95 (18): 10860–5. Bibcode:1998PNAS...9510860W. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.

[Yamamoto_2011-8] Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J (2011). "NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function". Cell. 147 (4): 827–839. doi:10.1016/j.cell.2011.10.017. PMC 3225739. PMID 22078881.

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