Nucleoporin 214

NUP214
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OIT, 3FHC, 3FMO, 3FMP, 5DIS
Identifiers
Aliases	NUP214, CAIN, CAN, D9S46E, N214, p250, nucleoporin 214kDa, nucleoporin 214, IIAE9
External IDs	OMIM: 114350; MGI: 1095411; HomoloGene: 38008; GeneCards: NUP214; OMA:NUP214 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	131,234,663 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,943,987 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; monocyte; ; granulocyte; ; testicle; ; epithelium of colon; ; blood; ; bone marrow cells; ; sural nerve; ; spleen;
	Top expressed in
	zygote; ; tail of embryo; ; secondary oocyte; ; genital tubercle; ; blastocyst; ; morula; ; embryo; ; endocardial cushion; ; spermatid; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nuclear export signal receptor activity; protein binding; nuclear localization sequence binding; structural constituent of nuclear pore;
Cellular component	cytosol; intracellular membrane-bounded organelle; focal adhesion; nucleoplasm; nucleus; cytoplasmic side of nuclear pore; nuclear pore nuclear basket; nuclear pore central transport channel; nuclear pore; nuclear envelope; host cell;
Biological process	mRNA transport; regulation of mRNA stability; regulation of cell cycle; protein export from nucleus; protein transport; viral process; protein import into nucleus; RNA export from nucleus; mRNA export from nucleus; regulation of nucleocytoplasmic transport; mitotic cell cycle; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	8021
	227720
	ENSG00000126883
	ENSMUSG00000001855
	P35658
	Q80U93
	NM_005085; NM_001318324; NM_001318325
	NM_172268
	NP_001305253; NP_001305254; NP_005076
	NP_758472; NP_001395026
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126883 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001855 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kraemer D, Wozniak RW, Blobel G, Radu A (Feb 1994). "The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm". Proceedings of the National Academy of Sciences of the United States of America. 91 (4): 1519–23. Bibcode:1994PNAS...91.1519K. doi:10.1073/pnas.91.4.1519. PMC 43191. PMID 8108440.
^ von Lindern M, Poustka A, Lerach H, Grosveld G (Aug 1990). "The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34". Molecular and Cellular Biology. 10 (8): 4016–26. doi:10.1128/mcb.10.8.4016. PMC 360912. PMID 2370860.
^ "Entrez Gene: NUP214 nucleoporin 214kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126883 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8108440-5] Kraemer D, Wozniak RW, Blobel G, Radu A (Feb 1994). "The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm". Proceedings of the National Academy of Sciences of the United States of America. 91 (4): 1519–23. Bibcode:1994PNAS...91.1519K. doi:10.1073/pnas.91.4.1519. PMC 43191. PMID 8108440.

[pmid2370860-6] von Lindern M, Poustka A, Lerach H, Grosveld G (Aug 1990). "The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34". Molecular and Cellular Biology. 10 (8): 4016–26. doi:10.1128/mcb.10.8.4016. PMC 360912. PMID 2370860.

[entrez-7] "Entrez Gene: NUP214 nucleoporin 214kDa".

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