| O'Reilly Senior High School | |
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| Address | |
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1St Circular Cl, Okpoi Gonno , P. O. Box 238 Ghana | |
| Coordinates | 05°37′36.1884″N 0°06′58.392″W / 5.626719000°N 0.11622000°W |
| Information | |
| Former names | O'Reilly Secondary School |
| School type | Boarding and day secondary school |
| Motto | Ztmkete (Steadfast) |
| Religious affiliation(s) | Non-denominational Christian |
| Denomination | Non-denominational |
| Opened | 25 August 1925 |
| Founder | Ezekiel Festus O'Reilly |
| Status | Active |
| School board | Board of Governors |
| School district | Ledzokuku-Krowor Municipal District |
| Authority | Ministry of Education |
| Oversight | Ghana Education Service |
| Chairperson | Chairperson of the Board of Governors |
| Grades | Forms 1–3 (10th–12th grades) |
| Gender | Co-educational |
| Age range | 14 to 18 years |
| Enrollment | ca. 1,200 |
| Education system | Senior High School |
| Language | English |
| Campus | 1St Circular Cl, Teshie Okpoi Gonno (GZ-148-1345) |
| Campus size | 1,300 acres (525 hectares) |
| Campus type | Residential garden-style Setting |
| Houses | 4 |
| Colour(s) | Blue and White |
| Slogan | Anyɛɛwɔ!!! |
| Song | "We are Student of O'Reilly School" |
| Nickname | O'REISCO |
| Publication | "The O'Reiscan" |
| Address | P. O. Box 238, Adabraka, Accra, Greater Accra, Ghana  |
| Website | oreillyseniorhighschool |
O'Reilly Senior High School (/əʊˈraɪliː/ oh-RY-lee), popularly known as "O'REISCO" is a co-educational boarding school located at Okpoi-Gonno in the Ledzokuku-Krowor Municipal District, Accra, Ghana.