O-class submarine may refer to:
- United States O-class submarine
- Oberon-class submarine
- Odin-class submarine
- Several early submarine classes of the Royal Netherlands Navy:
- O 1-class submarine consisting only HNLMS O 1
- O 2-class submarine
- O 6-class submarine consisting only HNLMS O 6
- O 7-class submarine consisting only HNLMS O 7
- O 9-class submarine
- O 12-class submarine
- O 16-class submarine consisting only HNLMS O 16
- O 19-class submarine
- O 21-class submarine
This disambiguation page lists articles associated with the title O-class submarine.
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