OAS1

OAS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IG8
Identifiers
Aliases	OAS1, IFI-4, OIAS, OIASI, E18/E16, 2'-5'-oligoadenylate synthetase 1
External IDs	OMIM: 164350; MGI: 2180860; HomoloGene: 1903; GeneCards: OAS1; OMA:OAS1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	112,933,219 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,045,584 bp
RNA expression pattern
	Top expressed in
	monocyte; ; mucosa of transverse colon; ; granulocyte; ; rectum; ; mucosa of esophagus; ; mucosa of ileum; ; spleen; ; gallbladder; ; nasal epithelium; ; right lobe of liver;
	Top expressed in
	granulocyte; ; jejunum; ; ileum; ; colon; ; duodenum; ; placenta; ; yolk sac; ; blastocyst; ; thymus; ; bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; metal ion binding; protein binding; RNA binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; extracellular region; endoplasmic reticulum; mitochondrion; nucleus; cytosol; nucleoplasm;
Biological process	purine nucleotide biosynthetic process; regulation of ribonuclease activity; glucose homeostasis; interferon-gamma-mediated signaling pathway; immune system process; response to virus; negative regulation of viral genome replication; defense response to virus; type I interferon signaling pathway; protein complex oligomerization; immune response; glucose metabolic process; cellular response to interferon-alpha; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	4938
	246730
	ENSG00000089127
	ENSMUSG00000052776
	P00973
	P11928
	NM_001032409; NM_002534; NM_016816; NM_001320151
	NM_145211
	NP_001027581; NP_001307080; NP_002525; NP_058132
	NP_660212
	Wikidata
View/Edit Human	View/Edit Mouse

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.^[5]^[6]

This gene encodes a member of the 2-5A synthetase family, which include essential proteins involved in the innate immune response to viral infection.

The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Hypomorphic mutations in this gene have been associated with host susceptibility to viral infection, while gain-of-function variants can cause autoinflammatory immunodeficiency.^[7] Alternatively spliced transcript variants encoding different isoforms have been described.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089127 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052776 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, et al. (October 1997). "A sequence-ready physical map of a region of 12q24.1". Genomics. 45 (2): 271–278. doi:10.1006/geno.1997.4888. PMID 9344649.
^ Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, et al. (September 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics. 44 (3): 321–329. doi:10.1006/geno.1997.4886. PMID 9325053.
^ Magg T, Okano T, Koenig LM, Boehmer DF, Schwartz SL, Inoue K, et al. (June 2021). "Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency". Science Immunology. 6 (60): eabf9564. doi:10.1126/sciimmunol.abf9564. PMC 8392508. PMID 34145065.
^ "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089127 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052776 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9344649-5] Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, et al. (October 1997). "A sequence-ready physical map of a region of 12q24.1". Genomics. 45 (2): 271–278. doi:10.1006/geno.1997.4888. PMID 9344649.

[pmid9325053-6] Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, et al. (September 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics. 44 (3): 321–329. doi:10.1006/geno.1997.4886. PMID 9325053.

[7] Magg T, Okano T, Koenig LM, Boehmer DF, Schwartz SL, Inoue K, et al. (June 2021). "Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency". Science Immunology. 6 (60): eabf9564. doi:10.1126/sciimmunol.abf9564. PMC 8392508. PMID 34145065.

[entrez-8] "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa".

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