OLR1

OLR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YPO, 1YPQ, 1YPU, 1YXJ, 1YXK, 3VLG
Identifiers
Aliases	OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1, oxidized low density lipoprotein receptor 1
External IDs	OMIM: 602601; MGI: 1261434; HomoloGene: 1910; GeneCards: OLR1; OMA:OLR1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,172,138 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,484,128 bp
RNA expression pattern
	Top expressed in
	right lung; ; C1 segment; ; bone marrow cells; ; upper lobe of left lung; ; lower lobe of lung; ; placenta; ; corpus callosum; ; testicle; ; appendix; ; gallbladder;
	Top expressed in
	gastrula; ; decidua; ; granulocyte; ; right lung lobe; ; embryo; ; tibiofemoral joint; ; primordial ventricle; ; blastocyst; ; uterus; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; carbohydrate binding; identical protein binding;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; receptor complex; plasma membrane; integral component of plasma membrane; nucleoplasm; extracellular region; membrane raft; specific granule membrane; tertiary granule membrane;
Biological process	immune system process; blood circulation; proteolysis; cell adhesion; inflammatory response; leukocyte migration; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	4973
	108078
	ENSG00000173391
	ENSMUSG00000030162
	P78380
	Q9EQ09
	NM_001172632; NM_001172633; NM_002543
	NM_001301094; NM_001301096; NM_138648
	NP_001166103; NP_001166104; NP_002534
	NP_001288023; NP_001288025; NP_619589
	Wikidata
View/Edit Human	View/Edit Mouse

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.^[5]^[6]

LOX-1 is the main receptor for oxidized LDL on endothelial cells, macrophages, smooth muscle cells,^[7] and other cell types.^[8] But minimally oxidized LDL is more readily recognized by the TLR4 receptor, and highly oxidized LDL is more readily recognized by the CD36 receptor.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173391 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030162 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li X, Bouzyk MM, Wang X (Nov 1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene". Cytogenet Cell Genet. 82 (1–2): 34–6. doi:10.1159/000015059. PMID 9763655. S2CID 46772688.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Pirillo A, Norata GD, Catapano AL (2013). "LOX-1, OxLDL, and atherosclerosis". Mediators of Inflammation. 2013: 1–12. doi:10.1155/2013/152786. PMC 3723318. PMID 23935243.
^ Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P (2013). "LOX-1 in atherosclerosis: biological functions and pharmacological modifiers". Cellular and Molecular Life Sciences. 70 (16): 2859–2872. doi:10.1007/s00018-012-1194-z. PMC 4142049. PMID 23124189.
^ Zmysłowski A, Szterk A (2017). "Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols". Lipids in Health and Disease. 16 (1): 188. doi:10.1186/s12944-017-0579-2. PMC 5625595. PMID 28969682.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173391 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030162 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9763655-5] Li X, Bouzyk MM, Wang X (Nov 1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene". Cytogenet Cell Genet. 82 (1–2): 34–6. doi:10.1159/000015059. PMID 9763655. S2CID 46772688.

[entrez-6] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid23935243-7] Pirillo A, Norata GD, Catapano AL (2013). "LOX-1, OxLDL, and atherosclerosis". Mediators of Inflammation. 2013: 1–12. doi:10.1155/2013/152786. PMC 3723318. PMID 23935243.

[pmid23124189-8] Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P (2013). "LOX-1 in atherosclerosis: biological functions and pharmacological modifiers". Cellular and Molecular Life Sciences. 70 (16): 2859–2872. doi:10.1007/s00018-012-1194-z. PMC 4142049. PMID 23124189.

[pmid28969682-9] Zmysłowski A, Szterk A (2017). "Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols". Lipids in Health and Disease. 16 (1): 188. doi:10.1186/s12944-017-0579-2. PMC 5625595. PMID 28969682.

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