OPN1LW

OPN1LW
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOPN1LW, CBBM, CBP, COD5, RCP, ROP, opsin 1 (cone pigments), long-wave-sensitive, opsin 1, long wave sensitive
External IDsOMIM: 300822; MGI: 1097692; HomoloGene: 68064; GeneCards: OPN1LW; OMA:OPN1LW - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020061

NM_008106

RefSeq (protein)

NP_064445

NP_032132

Location (UCSC)Chr X: 154.14 – 154.16 MbChr X: 73.17 – 73.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OPN1LW is a gene on the X chromosome that encodes for long wave sensitive (LWS) opsin, or red cone photopigment.[5] It is responsible for perception of visible light in the yellow-green range on the visible spectrum (around 500-570nm).[6][7] The gene contains 6 exons with variability that induces shifts in the spectral range.[8] OPN1LW is subject to homologous recombination with OPN1MW, as the two have very similar sequences.[8] These recombinations can lead to various vision problems, such as red-green colourblindness and blue monochromacy.[9] The protein encoded is a G-protein coupled receptor with embedded 11-cis-retinal, whose light excitation causes a cis-trans conformational change that begins the process of chemical signalling to the brain.[10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102076Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031394Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cite error: The named reference NCBI was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference Hofmann_2015 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference Merbs_1992 was invoked but never defined (see the help page).
  8. ^ a b Cite error: The named reference Neitz_2011 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference Genetics Home Reference was invoked but never defined (see the help page).
  10. ^ Cite error: The named reference Imamoto_2014 was invoked but never defined (see the help page).