ORC2

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex subunit 2
Origin recognition complex subunit 2
Identifiers
Symbol	ORC2
Pfam	PF04084
InterPro	IPR007220
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ORC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5C8H
Identifiers
Aliases	ORC2, ORC2L, origin recognition complex subunit 2
External IDs	OMIM: 601182; MGI: 1328306; HomoloGene: 4512; GeneCards: ORC2; OMA:ORC2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	200,963,680 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,544,268 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; buccal mucosa cell; ; gastric mucosa; ; body of pancreas; ; secondary oocyte; ; skin of leg; ; right testis; ; left testis;
	Top expressed in
	spermatocyte; ; fetal liver hematopoietic progenitor cell; ; tail of embryo; ; medullary collecting duct; ; ventricular zone; ; epiblast; ; spermatid; ; genital tubercle; ; Paneth cell; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA replication origin binding;
Cellular component	heterochromatin; inner kinetochore; nuclear origin of replication recognition complex; centrosome; chromatin; origin recognition complex; membrane; nucleoplasm; nucleus;
Biological process	G1 phase; DNA replication; negative regulation of transcription by RNA polymerase II; DNA replication initiation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	4999
	18393
	ENSG00000115942
	ENSMUSG00000026037
	Q13416
	Q60862
	NM_006190
	NM_001025378; NM_001271526; NM_008765
	NP_006181
	NP_001020549; NP_001258455; NP_032791
	Wikidata
View/Edit Human	View/Edit Mouse

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115942 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026037 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takahara K, Bong M, Brevard R, Eddy RL, Haley LL, Sait SJ, Shows TB, Hoffman GG, Greenspan DS (October 1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics. 31 (1): 119–122. doi:10.1006/geno.1996.0018. PMID 8808289.
^ "Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115942 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026037 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8808289-5] Takahara K, Bong M, Brevard R, Eddy RL, Haley LL, Sait SJ, Shows TB, Hoffman GG, Greenspan DS (October 1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics. 31 (1): 119–122. doi:10.1006/geno.1996.0018. PMID 8808289.

[entrez-6] "Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast)".

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