ORC3

ORC3
Identifiers
Aliases	ORC3, LAT, LATHEO, ORC3L, origin recognition complex subunit 3
External IDs	OMIM: 604972; MGI: 1354944; HomoloGene: 8225; GeneCards: ORC3; OMA:ORC3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,667,453 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	34,614,944 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; Achilles tendon; ; ventricular zone; ; glutes; ; gonad; ; embryo; ; ganglionic eminence; ; testicle; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	genital tubercle; ; tail of embryo; ; spermatocyte; ; epiblast; ; zygote; ; ventricular zone; ; maxillary prominence; ; neural layer of retina; ; mandibular prominence; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA replication origin binding; protein binding;
Cellular component	nuclear origin of replication recognition complex; origin recognition complex; nucleus; nucleoplasm; nuclear pre-replicative complex; DNA replication preinitiation complex; nuclear body;
Biological process	G1 phase; DNA replication; neural precursor cell proliferation; DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	23595
	50793
	ENSG00000135336
	ENSMUSG00000040044
	Q9UBD5
	Q9JK30
	NM_001197259; NM_012381; NM_181837
	NM_001159563; NM_015824
	NP_001184188; NP_036513; NP_862820
	NP_001153035; NP_056639
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex (ORC) subunit 3 N-terminus
Origin recognition complex (ORC) subunit 3 N-terminus
Identifiers
Symbol	ORC3_N
Pfam	PF07034
InterPro	IPR010748
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135336 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040044 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.
^ Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192. S2CID 781511.
^ "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135336 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040044 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9829972-5] Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.

[pmid10402192-6] Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192. S2CID 781511.

[entrez-7] "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)".

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