ORC4

ORC4
Identifiers
Aliases	ORC4, ORC4L, ORC4P, origin recognition complex subunit 4
External IDs	OMIM: 603056; MGI: 1347043; HomoloGene: 8059; GeneCards: ORC4; OMA:ORC4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	148,021,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	48,840,289 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; oocyte; ; islet of Langerhans; ; ganglionic eminence; ; kidney tubule; ; bronchial epithelial cell; ; corpus callosum; ; endothelial cell; ; ventricular zone; ; right uterine tube;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; spermatocyte; ; tail of embryo; ; ventricular zone; ; neural layer of retina; ; embryo; ; epiblast; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; DNA replication origin binding; protein binding; ATP binding;
Cellular component	nuclear origin of replication recognition complex; nucleolus; origin recognition complex; nucleus; nucleoplasm; cytosol;
Biological process	G1 phase; DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5000
	26428
	ENSG00000115947
	ENSMUSG00000026761
	O43929
	O88708
NM_001190879; NM_001190881; NM_001190882; NM_002552; NM_181741;
	NM_181742; NM_001374270; NM_001374272
	NM_001177313; NM_011958; NM_001355296
NP_001177808; NP_001177810; NP_001177811; NP_002543; NP_859525;
	NP_859526; NP_001361199; NP_001361201
	NP_001170784; NP_036088; NP_001342225
	Wikidata
View/Edit Human	View/Edit Mouse

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115947 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276.
^ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.
^ "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115947 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9353276-5] Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276.

[pmid9691185-6] Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.

[entrez-7] "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]