OS9 (gene)

OS9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AIH
Identifiers
Aliases	OS9, ERLEC2, OS-9, endoplasmic reticulum lectin, OS9 endoplasmic reticulum lectin
External IDs	OMIM: 609677; MGI: 1924301; HomoloGene: 31409; GeneCards: OS9; OMA:OS9 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,721,557 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	126,957,000 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tendon of biceps brachii; ; stromal cell of endometrium; ; monocyte; ; granulocyte; ; body of pancreas; ; islet of Langerhans; ; minor salivary glands; ; right lobe of thyroid gland; ; mucosa of ileum;
	Top expressed in
	lacrimal gland; ; neural layer of retina; ; submandibular gland; ; granulocyte; ; right kidney; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; parotid gland; ; superior frontal gyrus; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding; protein binding; protease binding;
Cellular component	Hrd1p ubiquitin ligase complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; endoplasmic reticulum;
Biological process	protein targeting; protein retention in ER lumen; negative regulation of retrograde protein transport, ER to cytosol; protein ubiquitination; ubiquitin-dependent ERAD pathway; response to endoplasmic reticulum stress; endoplasmic reticulum mannose trimming; transmembrane transport; ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol;
	Sources:Amigo / QuickGO
Orthologs
	10956
	216440
	ENSG00000135506
	ENSMUSG00000040462
	Q13438
	Q8K2C7
NM_001017956; NM_001017957; NM_001017958; NM_001261420; NM_001261421;
	NM_001261422; NM_001261423; NM_006812
	NM_001171026; NM_177614
NP_001017956; NP_001017957; NP_001017958; NP_001248349; NP_001248350;
	NP_001248351; NP_001248352; NP_006803
	NP_001164497; NP_808282
	Wikidata
View/Edit Human	View/Edit Mouse

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.^[5]^[6]^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135506 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040462 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Su YA, Hutter CM, Trent JM, Meltzer PS (Apr 1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085. S2CID 23490951.
^ Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M (Dec 1997). "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry. 122 (6): 1190–5. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.
^ Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K (Jun 2009). "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry. 284 (25): 17061–8. doi:10.1074/jbc.M809725200. PMC 2719344. PMID 19346256.
^ Christianson JC, Shaler TA, Tyler RE, Kopito RR (Mar 2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077. PMID 18264092.
^ "Entrez Gene: OS9 amplified in osteosarcoma".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135506 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040462 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8634085-5] Su YA, Hutter CM, Trent JM, Meltzer PS (Apr 1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085. S2CID 23490951.

[pmid9498564-6] Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M (Dec 1997). "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry. 122 (6): 1190–5. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.

[pmid19346256-7] Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K (Jun 2009). "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry. 284 (25): 17061–8. doi:10.1074/jbc.M809725200. PMC 2719344. PMID 19346256.

[pmid18264092-8] Christianson JC, Shaler TA, Tyler RE, Kopito RR (Mar 2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077. PMID 18264092.

[entrez-9] "Entrez Gene: OS9 amplified in osteosarcoma".

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