OTX1

OTX1
Identifiers
Aliases	OTX1, orthodenticle homeobox 1
External IDs	OMIM: 600036; MGI: 97450; HomoloGene: 7875; GeneCards: OTX1; OMA:OTX1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	63,057,836 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	21,952,897 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; ventricular zone; ; ganglionic eminence; ; minor salivary glands; ; skin of leg; ; skin of abdomen; ; testicle; ; nasal epithelium; ; amygdala; ; cingulate gyrus;
	Top expressed in
	nasolacrimal duct; ; lip; ; ventricular zone; ; lacrimal gland; ; optic nerve; ; ciliary body; ; iris; ; zygote; ; thyroglossal duct; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	diencephalon morphogenesis; regulation of transcription by RNA polymerase II; multicellular organism development; metencephalon development; forebrain development; regulation of transcription, DNA-templated; inner ear morphogenesis; midbrain development; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5013
	18423
	ENSG00000115507
	ENSMUSG00000005917
	P32242
	P80205
	NM_001199770; NM_014562
	NM_011023
	NP_001186699; NP_055377
	NP_035153
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115507 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005917 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (July 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.
^ "Entrez Gene: OTX1 orthodenticle homeobox 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115507 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005917 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7959790-5] Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (July 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.

[entrez-6] "Entrez Gene: OTX1 orthodenticle homeobox 1".

[1]

[2]

[3]

[4]

[5]

[6]