Oconee was a tribal town of Hitchiti-speaking Indigenous peoples of the Southeastern Woodlands during the 17th and 18th centuries.
First mentioned by the Spanish as part of the Apalachicola Province on the Chattahoochee River, Oconee moved with other towns of the province to central Georgia between 1690 and 1692. In 1715, early in the Yamasee War, Oconee and the other towns of the former Apalachicola Province moved back to the Chattahoochee River. Around 1750, part of the people of Oconee, under the leadership of Ahaya, moved to Florida, settling next to the Alachua Prairie.
The members of the tribal town in Florida were joined by people from other Hitchiti-speaking towns and became Seminoles. The remaining Oconee members stayed on the Chattahoochee River through the 18th century.