Odoardo Farnese (6 December 1573 – 21 February 1626) was an Italian nobleman, the second son of Alessandro Farnese, Duke of Parma and Maria of Portugal, known for his patronage of the arts. He became a Cardinal of the Roman Catholic Church in 1591, and briefly acted as regent of the Duchy of Parma and Piacenza for his nephew Odoardo from 1622 to 1626.
Cardinal Odoardo is probably best known today for commissioning the Bolognese artist Annibale Carracci to fresco the Camerino in the Palazzo Farnese in Rome. Carracci undertook this from 1595 to 1597, just prior to starting his decoration of the more famous and elaborate Farnese Gallery in the same palace.