Ohio State Route 278

State Route 278
Route information
Maintained by ODOT
Length	27.61 mi[1] (44.43 km)
Existed	1930–present
Major junctions
South end	US 50 near McArthur
Major intersections	US 33 Bus. in Nelsonville
North end	SR 595 near Nelsonville
Location
Country	United States
State	Ohio
Counties	Vinton, Hocking, Athens
Highway system
Ohio State Highway System Interstate US State Scenic
← SR 277 → SR 279

State Route 278 (SR 278) is a north–south state highway located in the southeastern part of the U.S. state of Ohio. The southern terminus of SR 278 is at US 50 approximately 4.75 miles (7.64 km) east of McArthur. The highway's northern terminus is at the T-intersection it has with SR 595 nearly 5.50 miles (8.85 km) northwest of Nelsonville.

Established in the early 1930s, SR 278 primarily connects rural communities in Vinton, Hocking, and Athens Counties. In Vinton County, it passes through and provides access to the Zaleski State Forest and Lake Hope State Park.