State Route 279 (SR 279) is a 20.11-mile-long (32.36 km) east–west state highway in the southern portion of the U.S. state of Ohio. The western terminus of SR 279 is at a T-intersection with SR 139 nearly 5.25 miles (8.45 km) northwest of South Webster. Its eastern terminus is at a T-intersection with U.S. Route 35 (US 35) approximately 0.25 miles (0.40 km) east of the village of Centerville.