Olaflur

Olaflur
Clinical data
Other names	{3-[Octadecyl(2-hydroxyethyl)aminio]propyl}bis(2-hydroxyethyl)amine dihydrofluoride
AHFS/Drugs.com	International Drug Names
Pregnancy; category	No adequate studies;
Routes of; administration	Topical (toothpaste, mouthwash, gel)
ATC code	A01AA03 (WHO) ;
Legal status
Legal status	In general: Over-the-counter (OTC);
Identifiers
	IUPAC name N,N,N'-tris(2-hydroxyethyl)-N'-octadecylpropane-1,3-diamine dihydrofluoride;
CAS Number	6818-37-7 ;
PubChem CID	23257;
ChemSpider	21751 ;
UNII	8NY9L8837D;
CompTox Dashboard (EPA)	DTXSID40987684 ;
ECHA InfoCard	100.027.174
Chemical and physical data
Formula	C27H60F2N2O3
Molar mass	498.785 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES F.F.OCCN(CCCN(CCCCCCCCCCCCCCCCCC)CCO)CCO;
	InChI InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32;;/h30-32H,2-27H2,1H3;2*1H ; Key:ZVVSSOQAYNYNPP-UHFFFAOYSA-N ;
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Olaflur (INN, or amine fluoride 297) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries.^[1] It has been in use since 1966. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel.^[2]

^ Ganss C, Klimek J, Brune V, Schürmann A (2004). "Effects of two fluoridation measures on erosion progression in human enamel and dentine in situ". Caries Research. 38 (6): 561–6. doi:10.1159/000080587. PMID 15528912. S2CID 12683542.
^ Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-196-8.

[1] Ganss C, Klimek J, Brune V, Schürmann A (2004). "Effects of two fluoridation measures on erosion progression in human enamel and dentine in situ". Caries Research. 38 (6): 561–6. doi:10.1159/000080587. PMID 15528912. S2CID 12683542.

[AustriaCodex-2] Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-196-8.

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