 | This article needs more reliable medical references for verification or relies too heavily on primary sources. (March 2013) |  |
 | Parts of this article (those related to HSV1716 clinical trials) need to be updated. (September 2015) |
| Oncolytic herpes virus | |
|---|---|
| |
| TEM micrograph of a herpes simplex virus. | |
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Duplodnaviria |
| Kingdom: | Heunggongvirae |
| Phylum: | Peploviricota |
| Class: | Herviviricetes |
| Order: | Herpesvirales |
| Family: | Orthoherpesviridae |
| Genus: | Simplexvirus |
| Species: | Human alphaherpesvirus 1
|
Many variants of herpes simplex virus have been considered for viral therapy of cancer; the early development of these was thoroughly reviewed in the journal Cancer Gene Therapy in 2002.[1] This page describes (in the order of development) the most notable variants—those tested in clinical trials: G207, HSV1716, NV1020 and Talimogene laherparepvec (previously Oncovex-GMCSF). These attenuated versions are constructed by deleting viral genes required for infecting or replicating inside normal cells but not cancer cells, such as ICP34.5, ICP6/UL39, and ICP47.
- ^ Varghese S, Rabkin SD (December 2002). "Oncolytic herpes simplex virus vectors for cancer virotherapy". Cancer Gene Therapy. 9 (12): 967–78. doi:10.1038/sj.cgt.7700537. PMID 12522436.