Onesimus (late 1600s–1700s[1]) was an African man who was instrumental in the mitigation of the impact of a smallpox outbreak in Boston, Massachusetts. His birth name is unknown. He was enslaved and, in 1706, was given to the New England Puritan minister Cotton Mather, who renamed him. Onesimus introduced Mather to the principle and procedure of the variolation method of inoculation to prevent the disease, which laid the foundation for the development of vaccines.[2] After a smallpox outbreak began in Boston in 1721, Mather used this knowledge to advocate for inoculation in the population. This practice eventually spread to other colonies. In a 2016 Boston magazine survey, Onesimus was declared one of the "Best Bostonians of All Time".[1]
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