The Ophis (Ancient Greek: Ὄφις), also called the Ophius or Ophious (Ὀφιοῦς),[1] was a river of ancient Pontus, the mouth of which was 90 stadia to the east of port Hyssus, and which separated Colchis from the country of the Thianni.[2]
It is identified with the modern Istala Dere in Asiatic Turkey.[3]