Opioid-induced endocrinopathy

Opioid-induced endocrinopathy (OIE) is a complication of chronic opioid treatment.[1][2][3] It is a common name for all hypothalamo-pituitary axis disorders, which can be observed mostly after long term use of opioids, both as a treatment and as a substance of abuse.[1]

The effect of opioids on hormonal levels can be measured immediately after the application of the opioid.[1] The onset of deficit mostly comes after longer time of use of high doses, but sometimes coexisting factor like cancer disease,[4][5] pain disease or other medicines may accelerate the progress.[1]

  1. ^ a b c d Fountas, Athanasios; Chai, Shu Teng; Kourkouti, Chrysoula; Karavitaki, Niki (October 2018). "MECHANISMS OF ENDOCRINOLOGY: Endocrinology of opioids". European Journal of Endocrinology. 179 (4): R183–R196. doi:10.1530/EJE-18-0270. ISSN 0804-4643. PMID 30299887.
  2. ^ Colameco, Stephen; Coren, Joshua S. (January 2009). "Opioid-induced endocrinopathy". The Journal of the American Osteopathic Association. 109 (1): 20–25. ISSN 1945-1997. PMID 19193821.
  3. ^ Rhodin, Annica; Stridsberg, Mats; Gordh, Torsten (June 2010). "Opioid Endocrinopathy: A Clinical Problem in Patients With Chronic Pain and Long-term Oral Opioid Treatment". The Clinical Journal of Pain. 26 (5): 374–380. doi:10.1097/AJP.0b013e3181d1059d. ISSN 0749-8047. PMID 20473043. S2CID 30105241.
  4. ^ Buss, Tomasz; Leppert, Wojciech (February 2014). "Opioid-Induced Endocrinopathy in Cancer Patients: An Underestimated Clinical Problem". Advances in Therapy. 31 (2): 153–167. doi:10.1007/s12325-014-0096-x. ISSN 0741-238X. PMID 24497073. S2CID 207417731.
  5. ^ Merdin, Alparslan; Merdin, Fatma Avci; Gündüz, Şeyda; Bozcuk, Hakan; Coşkun, Hasan Şenol (May 2016). "Opioid endocrinopathy: A clinical problem in patients with cancer pain". Experimental and Therapeutic Medicine. 11 (5): 1819–1822. doi:10.3892/etm.2016.3156. ISSN 1792-0981. PMC 4840782. PMID 27168810.