| Opoku Fofie | |
|---|---|
| Asantehene | |
 Representation of a porcupine: nickname given to the kingdom of Kumasi and emblem of the Ashanti Empire. | |
| Predecessor | Osei Kwame Panyin |
| Successor | Osei Bonsu |
| Born | circa 1775 |
| Died | March 1804 |
| Father | Adu Twum |
| Mother | Konadu Yaadom |
Opoku Fofie, born around 1775 and died in March 1804, was the sixth asantehene (monarch) of the Ashanti Empire, belonging to the dynastic house of Opoku Ware of the Oyoko clan. The youngest son of the asantehemaa (queen mother) Konadu Yaadom and Adu Twum Kaakyire, he acceded to the throne by the principle of dynastic alternation in force since the founding of the empire, after the crisis that opposed his mother to her predecessor Osei Kwame from 1797 to 1803.
The removal of Osei Kwame, followed by Barnabu's battle against his armed Muslim supporters in the tributary states of Gyaman and Kong, paved the way for his accession to the throne. His reign began in December 1803, coinciding with the ritual suicide of his predecessor, and lasted no more than sixty days. This situation gave rise to the myth of Osei Kwame's vengeful spirit (saman). Osei Bonsu succeeded him in 1804.
Official versions of Ashanti genealogy differ greatly from historical research, due to the numerous genealogical modifications aimed at erasing the existence of Akyaama in the lineage. Indeed, the asantehemaa are the guarantors of tradition, official genealogy, and succession to the asantehene throne. This conflict is at the root of the many divergences.