Optineurin

OPTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LO4, 2LUE, 5AAZ
Identifiers
Aliases	OPTN, ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, optineurin
External IDs	OMIM: 602432; MGI: 1918898; HomoloGene: 11085; GeneCards: OPTN; OMA:OPTN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	13,138,308 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	5,068,862 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; gastrocnemius muscle; ; muscle of thigh; ; glutes; ; triceps brachii muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; tendon; ; tendon of biceps brachii; ; thoracic diaphragm;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; jejunum; ; iris; ; retinal pigment epithelium; ; spermatid; ; myocardium of ventricle; ; seminiferous tubule; ; interventricular septum; ; knee joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein C-terminus binding; protein binding; identical protein binding; K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; polyubiquitin modification-dependent protein binding;
Cellular component	recycling endosome; endosome; Golgi membrane; nucleoplasm; autophagosome; trans-Golgi network; perinuclear region of cytoplasm; nucleus; Golgi apparatus; cytoplasm; cytosol; recycling endosome membrane; cytoplasmic vesicle;
Biological process	Golgi organization; cell death; negative regulation of I-kappaB kinase/NF-kappaB signaling; autophagy; G2/M transition of mitotic cell cycle; defense response to Gram-negative bacterium; negative regulation of receptor recycling; vesicle-mediated transport; regulation of I-kappaB kinase/NF-kappaB signaling; signal transduction; Golgi to plasma membrane protein transport; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; positive regulation of xenophagy; positive regulation of autophagy; Unfolded Protein Response; Golgi ribbon formation; immune system process; innate immune response; protein localization to Golgi apparatus;
	Sources:Amigo / QuickGO
Orthologs
	10133
	71648
	ENSG00000123240
	ENSMUSG00000026672
	Q96CV9
	Q8K3K8
	NM_001008211; NM_001008212; NM_001008213; NM_021980
	NM_181848; NM_001356487
	NP_001008212; NP_001008213; NP_001008214; NP_068815
	NP_862896; NP_001343416
	Wikidata
View/Edit Human	View/Edit Mouse

Optineurin is a protein that in humans is encoded by the OPTN gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123240 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026672 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Héon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M (February 2002). "Adult-onset primary open-angle glaucoma caused by mutations in optineurin". Science. 295 (5557): 1077–9. Bibcode:2002Sci...295.1077R. doi:10.1126/science.1066901. PMID 11834836. S2CID 23635499.
^ Li Y, Kang J, Horwitz MS (March 1998). "Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains". Molecular and Cellular Biology. 18 (3): 1601–10. doi:10.1128/mcb.18.3.1601. PMC 108875. PMID 9488477.
^ "Entrez Gene: OPTN optineurin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123240 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026672 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11834836-5] Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Héon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M (February 2002). "Adult-onset primary open-angle glaucoma caused by mutations in optineurin". Science. 295 (5557): 1077–9. Bibcode:2002Sci...295.1077R. doi:10.1126/science.1066901. PMID 11834836. S2CID 23635499.

[pmid9488477-6] Li Y, Kang J, Horwitz MS (March 1998). "Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains". Molecular and Cellular Biology. 18 (3): 1601–10. doi:10.1128/mcb.18.3.1601. PMC 108875. PMID 9488477.

[entrez-7] "Entrez Gene: OPTN optineurin".

[1]

[2]

[3]

[4]

[5]

[6]

[7]