Organ bath

Not to be confused with Isolated organ perfusion technique.
Diagram of a typical organ bath preparation. An excised piece of smooth muscle tissue is held in an oxygenated solution in a chamber. The tissue is attached to a lever, which transmits its contraction to a myograph, thus recording the physiological response. Drugs under investigation can be administered directly to the chamber.

An organ chamber, organ bath, or isolated tissue bath, is a chamber in which isolated organs or tissues can be administered with drugs, or stimulated electrically, in order to measure their function. The tissue in the organ bath is typically oxygenated with carbogen and kept in a solution such as Tyrode's solution or lactated Ringer's solution.[citation needed] Historically, they have also been called gut baths.[1]

  1. ^ Handley, Sheila L.; Singh, Lakhbir (January 1986). "Neurotransmitters and shaking behaviour — more than a 'gut-bath' for the brain?". Trends in Pharmacological Sciences. 7: 324–328. doi:10.1016/0165-6147(86)90371-8.