Orthodenticle

Orthodenticle (otd) is a homeobox gene found in Drosophila that regulates the development of anterior patterning, with particular involvement in the central nervous system function and eye development.[1] It is located on the X chromosome.[1] The gene is an ortholog of the human OTX1/OTX2 gene.[2]

  1. ^ a b Finkelstein R, Smouse D, Capaci TM, Spradling AC, Perrimon N (July 1990). "The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures". Genes & Development. 4 (9): 1516–1527. doi:10.1101/gad.4.9.1516. PMID 1979296.
  2. ^ Leuzinger S, Hirth F, Gerlich D, Acampora D, Simeone A, Gehring WJ, Finkelstein R, Furukubo-Tokunaga K, Reichert H (April 1998). "Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila". Development. 125 (9): 1703–1710. doi:10.1242/dev.125.9.1703. PMID 9521908.