Osteolathyrism

Osteolathyrism
Other namesOdoratism, Lathyrism[1]
SpecialtyRheumatology
Symptomsskeletal deformities, bone pain[2]
DurationPermanent[2]
CausesOver consumption of Lathyrus sativus[2]
FrequencyRare

Osteolathyrism, sometimes referred to as odoratism, is a form of the disease Lathyrism.[1] The disease results from the ingestion of Lathyrus odoratus seeds (sweet peas). The toxin found in the sweet peas is (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues.[3] The condition results in damage to bone and mesenchymal connective tissues.[3] Osteolathyrism occurs in people in combination with neurolathyrism and angiolathyrism in areas where famine demands reliance on a crop with known detrimental effects. It occurs in cattle and horses with diets overreliant upon the grass pea. Prominent symptoms include skeletal deformities and bone pain.[2]

  1. ^ a b Dasler, Waldemar; Mosby, Mildred (November 1954). "Incisor Ash Versus Femur Ash in Sweet Pea Lathyrism (Odoratism)". The Journal of Nutrition. 54 (3): 397–402. doi:10.1093/jn/54.3.397. PMID 13212476.
  2. ^ a b c d Haque, Abdul; Hossain, Muffazal; Lambien, Fernand; Bell, E. Arthur (May 2006). "Evidence of Osteolathyrism among patients suffering from Neurolathyrism in Bangladesh". Natural Toxins. 5 (1): 43–6. doi:10.1002/(SICI)(1997)5:1<43::AID-NT7>3.0.CO;2-M. PMID 9086459.
  3. ^ a b Rosenthal, Gerald (2003). "Toxic Constituents and their Related Metabolites". Plant Nonprotein Amino and Imino Acids: Biological, Biochemical, and Toxicological Properties. Elsevier. ISBN 9780323157742.