Osteopontin

SPP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin
External IDsOMIM: 166490; MGI: 98389; HomoloGene: 20156; GeneCards: SPP1; OMA:SPP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001251830
NM_000582
NM_001040058
NM_001040060
NM_001251829

NM_001204201
NM_001204202
NM_001204203
NM_001204233
NM_009263

RefSeq (protein)

NP_001191130
NP_001191131
NP_001191132
NP_001191162
NP_033289

Location (UCSC)Chr 4: 87.98 – 87.98 MbChr 5: 104.58 – 104.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Osteopontin
Identifiers
SymbolOsteopontin
PfamPF00865
InterProIPR002038
PROSITEPDOC00689
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric),[5] is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts.

The prefix osteo- indicates that the protein is expressed in bone, although it is also expressed in other tissues. The suffix -pontin is derived from "pons," the Latin word for bridge, and signifies osteopontin's role as a linking protein. Osteopontin is an extracellular structural protein and therefore an organic component of bone.

The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.1). The protein is composed of ~300 amino acids residues and has ~30 carbohydrate residues attached, including 10 sialic acid residues, which are attached to the protein during post-translational modification in the Golgi apparatus. The protein is rich in acidic residues: 30-36% are either aspartic or glutamic acid.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118785Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029304Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SPP1 secreted phosphoprotein 1".