Otosclerosis

Otosclerosis
Other namesOtospongiosis
Chain of ossicles and their ligaments. (Stapes visible near center right.)
SpecialtyOtorhinolaryngology

Otosclerosis is a condition of the middle ear where portions of the dense enchondral layer of the bony labyrinth remodel into one or more lesions of irregularly-laid spongy bone. As the lesions reach the stapes the bone is resorbed, then hardened (sclerotized), which limits its movement and results in hearing loss, tinnitus, vertigo or a combination of these.[1][2][3][4] The term otosclerosis is something of a misnomer: much of the clinical course is characterized by lucent rather than sclerotic bony changes, so the disease is also known as otospongiosis.

  1. ^ "otosclerosis" at Dorland's Medical Dictionary
  2. ^ Uppal S, Bajaj Y, Rustom I, Coatesworth AP (October 2009). "Otosclerosis 1: the aetiopathogenesis of otosclerosis". International Journal of Clinical Practice. 63 (10): 1526–30. doi:10.1111/j.1742-1241.2009.02045.x. PMID 19769709. S2CID 11989071.
  3. ^ Ealy, Megan; Smith, Richard J. H. (2011). "Otosclerosis". Medical Genetics in the Clinical Practice of ORL. Advances in Oto-Rhino-Laryngology. 70: 122–129. doi:10.1159/000322488. ISBN 978-3-8055-9668-8. PMID 21358194.
  4. ^ Chole, Richard A.; McKenna, Michael (March 2001). "Pathophysiology of Otosclerosis". Otology & Neurotology. 22 (2): 249–257. doi:10.1097/00129492-200103000-00023. ISSN 1531-7129. PMID 11300278. S2CID 36262295. Retrieved 2022-10-07.