Oxilofrine

Not to be confused with Oxyfedrine.

Oxilofrine
Clinical data
Trade namesCarnigen, Cophylac, Suprifen, others
Other namesOxilophrine; Hydroxyephedrine; (±)-Hydroxyephedrine; 4-Hydroxyephedrine; p-Hydroxyephedrine; Oxyephedrine; Methylsynephrine; 4-HMP; 4,β-Dihydroxy-N-methyl-α-methylphenethylamine; 4,β-Dihydroxy-N-methylamphetamine
Routes of
administration		Oral[1]
ATC code
  • None
Legal status
Legal status
Identifiers
  • (1S*,2R*)-(±)-4-(1-Hydroxy-2-methylamino-propyl)phenol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.067 Edit this at Wikidata
Chemical and physical data
FormulaC10H15NO2
Molar mass181.235 g·mol−1
  • InChI=1S/C10H15NO2/c1-7(11-2)10(13)8-3-5-9(12)6-4-8/h3-7,10-13H,1-2H3 checkY
  • Key:OXFGTKPPFSCSMA-UHFFFAOYSA-N checkY
  (verify)

Oxilofrine, sold under the brand names Carnigen and Suprifen among others, is a sympathomimetic medication which has been used as an antihypotensive agent and cough suppressant.[4][5][6] It is taken by mouth.[1]

Oxilofrine acts as a norepinephrine releasing agent and hence is an indirectly acting sympathomimetic.[7][6][8] It is a substituted amphetamine and is closely related to ephedrine (with oxilofrine also being known as 4-hydroxyephedrine).[4][8]

Oxilofrine was first developed in the 1930s.[9] It is mostly no longer marketed today.[10]

  1. ^ a b Cite error: The named reference DrugBank was invoked but never defined (see the help page).
  2. ^ "Methylsynephrine in Dietary Supplements". FDA. February 22, 2023. Retrieved June 9, 2023.
  3. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  4. ^ a b Cite error: The named reference IndexNominum2000 was invoked but never defined (see the help page).
  5. ^ Fourcroy JL (2008). Pharmacology, doping and sports: a scientific guide for athletes, coaches, physicians, scientists and administrators. Taylor & Francis. ISBN 978-0-415-42845-3.
  6. ^ a b Cite error: The named reference Docherty2008 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference MortonHall2012 was invoked but never defined (see the help page).
  8. ^ a b Cite error: The named reference Derendorf1995 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference Cohen2017 was invoked but never defined (see the help page).
  10. ^ Cite error: The named reference Drugs.com-International was invoked but never defined (see the help page).