Genes on human chromosome 3
The oxytocin receptor , also known as OXTR , is a protein which functions as receptor for the hormone and neurotransmitter oxytocin .[ 4] [ 5] In humans, the oxytocin receptor is encoded by the OXTR gene [ 6] [ 7] which has been localized to human chromosome 3p25 .[ 8]
Evolutionary tree of the oxytocin, vasotocin , mesotocin and isotocin receptors and their ligands. From Koechbach et al.[ 9]
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049112 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Gimpl G, Fahrenholz F (April 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews . 81 (2): 629–83. doi :10.1152/physrev.2001.81.2.629 . PMID 11274341 . S2CID 13265083 .
^ Zingg HH, Laporte SA (July 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism . 14 (5): 222–7. doi :10.1016/S1043-2760(03)00080-8 . PMID 12826328 . S2CID 21540056 .
^ EntrezGene 5021
^ Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (April 1992). "Structure and expression of a human oxytocin receptor" (PDF) . Nature . 356 (6369): 526–9. Bibcode :1992Natur.356..526K . doi :10.1038/356526a0 . PMID 1313946 . S2CID 4273722 . Archived from the original (PDF) on 2017-09-21. Retrieved 2021-05-29 .
^ Simmons CF, Clancy TE, Quan R, Knoll JH (April 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics . 26 (3): 623–5. doi :10.1016/0888-7543(95)80188-R . PMID 7607693 .
^ Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (February 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding" . Biochemical Society Transactions . 41 (1): 197–204. doi :10.1042/BST20120256 . PMC 3634130 . PMID 23356283 .