Oz is a surname. Notable people with the surname include:
- Amos Oz (1939–2018), Israeli author
- Avraham Oz (born 1944), Israeli theatre professor
- Daphne Oz (born 1986), American author, chef, and television host
- Doğan Öz (1934–1978), Turkish prosecutor assassinated in the line of duty
- Frank Oz (born 1944), American film director, actor, and puppeteer
- Kobi Oz (born 1969), Israeli singer with the Teapacks
- Lisa Oz (born 1963), American author, television personality, and radio personality
- Mehmet Oz (born 1960), known as Dr. Oz, Turkish-American surgeon, television host, and politician
- Noyan Öz (born 1991), Turkish-German footballer